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The phenomenon of ligand-directed signalling bias for GLP-1R has recently been described using the endpoints of cAMP production, pERK1/2 and intracellular Ca 2+

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Move from 10 mg to 7.5 mg for 6 weeks, then 7.5 mg to 5 mg for 6 weeks, then 5 mg to 2.5 mg for 6 weeks before complete discontinuation