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Effects on Fibrosis (Tissue Stiffness) Fibrosis is a hallmark of lipedema and contributes to: Pain Tissue hardness Reduced response to treatment Tirzepatide has shown antifibrotic effects in other conditions (like fatty liver disease), suggesting it may help improve tissue quality over time

GLP-1, or glucagon-like peptide-1, plays a crucial role in weight loss

doi:10.1001/jamainternmed.2013.2720 80

Apparently, this might be the case for DCIP reduction by Trolox

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In addition, GSSG retained in mitochondria during oxidative stress can lead to the S-gluthionylation of target proteins with mitochondrial dysfunction (20, 21)