This is because the triple receptor agonist also activates GCG receptors in the liver and fat tissue, potentially enhancing fat breakdown in liver cells and the transformation of white fat to beige fat, which increases heat-generated energy expenditure [15]
Flore G, Preti A, Carta MG, et al
Clinical Considerations for Weight Loss on GLP-1 During Prednisone Treatment Prednisone itself promotes weight gain through increased appetite, cortisol-driven fat redistribution, and fluid retention
Ipamorelin produces substantially less appetite stimulation than GHRP-6 in animal models, despite activating the same receptor
Second: your body will tell you loud and clear (fullness, nausea, reflux)
Common side effects reported with retatrutide include: Nausea, vomiting, and diarrhoea (most frequent, particularly during dose escalation) Decreased appetite Constipation Injection site reactions Mild increases in heart rate Cagrilintide has demonstrated a generally well-tolerated profile, with gastrointestinal symptoms also being the most commonly reported adverse effects