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Semaglutide is highly protein-bound and not expected to be dialyzable
This action makes these agents a therapeutic option for weight loss.56 Although to a lesser extent, delay in gastric emptying contributes to the anorexigenic effect.61 Clinical trials conducted with GLP-1 receptor agonists in patients with obesity (or excess weight [BMI 27] with comorbidities), or with DT2 and excess weight or obesity, have achieved weight reductions greater than those reported for orlistat, as well as those observed with oral antidiabetic agents such as the sodium glucose type 2 cotransporter inhibitors (SGLT2i) or metformin.62 In a meta-analysis of more than 10 000 patients with obesity, those treated with GLP-1 receptor agonists lost, on average, 7kg more than those in the control group.63 Weight loss of up to 15% has been observed after 12 months of treatment,64,65 a level that had only been achieved through surgical methods
Hyperosmolar hyperglycemic state: a historic review of the clinical presentation, diagnosis, and treatment
A lack of comprehensive long-term data makes it difficult to accurately assess the true cost-effectiveness of these medications
Most GLP-1 side effects show significant improvement by week 3 to 4, with full adaptation typically occurring by week 6 to 8 for the majority of users
