Senescence-Associated Cell Transition and Interaction (SACTAI): A Proposed Mechanism for Tissue Aging, Repair, and Degeneration
Relevant clinical trials should assess outcomes such as sleep-onset latency, total sleep time, wakefulness after sleep onset, sleep efficiency, daytime functioning and patient-reported symptoms
MPTP for Parkinsons disease has been known since 1982 [224]
Science (1979) 373 , eabe4832 (2021)
More detailed morphometric analyses further revealed that this increase in bone density derived primarily from a reduction in trabecular spacing rather than an increase in trabecular thickness (Table S1)
The study identified increased proportions of pro-inflammatory and mesenchymal fibroblast subpopulations, elevated p16 protein and SA--galactosidase-positive cells, and enhanced SASP gene expression in keloid tissue