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In a case series of patients treated with antipsychotics who experienced inadequate weight loss on metformin, treatment with a mean semaglutide dose of 0.71 mg/week resulted in mean weight loss of 4.56 kg, 5.16 kg, and 8.67 kg at follow-up periods of 3, 6, and 12 months, respectively

It does suggest these agents stabilize reward circuitry and reduce pathologic cue-driven behavior

Patients with a history of hormone-sensitive conditions should discuss ipamorelin therapy with a healthcare professional to determine if it is suitable

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Public Health Impact Clinical data shows semaglutide can achieve ~15% body-weight reduction, making it one of the most effective pharmacological treatments available for obesity management