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Medicine 94 , e1783 (2015)

At the cellular level, research has examined GHK-Cu's activity in fibroblast biology and in genes involved in collagen, elastin, and proteoglycan synthesis - the structural proteins of the skin's extracellular matrix

In contrast, when placed under metabolic stress with increased demand on the -cell (induced by high fat feeding and a low dose of the -cell toxin, streptozotocin), glucose tolerance did become impaired, supporting the view that paracrine GLP-1 may be required to maintain glucose homeostasis during adaptation to metabolic stress (114)