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Research in animal models suggests the combination produces synergistic effects

GLP-1RAs in the cardiovascular system In the cardiovascular system, GLP-1 can reduce cardiac ischemia-reperfusion injury through the activation of specific signaling pathways, such as the PI3K/Akt pathway

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It also helps combat oxidative stress and inflammation , two major contributors to premature aging

This modification extends the peptides half-life from minutes (native IGF-1) to several hours and enhances systemic bioavailability [2]