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& Poulsen, R

For instance, a study found that semaglutide 1.0 mg once weekly plus basal insulin significantly reduced mean HbA1c (a measure of long-term blood sugar control) compared to insulin when taken over 26 weeks [10]

[5961] With increasing attention on the metabolic role of MSTN, a study demonstrated that inhibition of MSTN ameliorated type 1 diabetes in mice by improving insulin sensitivity and enhancing the expression of Glut1 and Glut4 glucose transporters in skeletal muscle.[62] This was found to be the same in humans as elevated circulating MSTN levels have also been found in patients with type 1 diabetes.[63] Collectively, these observations highlight the therapeutic potential of targeting MSTN for the treatment of metabolic disorders, including obesity and diabetes

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