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The standard industry response to a patent cliff is lifecycle management: launch a successor product, file secondary patents on the original, shift prescribing, and delay the effective date of generic competition

This phenomenon is well-documented in weight loss research, regardless of the method used to achieve weight reduction

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Nature PubMed Preclinical literature and narrative reviews describe pleiotropic actions including angiogenesis modulation (promotion in healing contexts and proposed inhibition in rodent corneal neovascularization models) and purported cytoprotective effects across diverse injury paradigms, but these remain unconfirmed in controlled human experiments