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It does not bind classical retinoic acid receptors (RARs) the way retinoids do, which is why it carries none of retinol's photosensitivity or purging risk

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M., Jensen, J., & Tordiffe, A

By activating amylin and calcitonin receptors in the brain, particularly within the hypothalamus and brainstem, Cagrilintide reduces food intake, promotes satiety, and contributes to sustained weight loss