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They are limitations and concerns drawn from the published scientific record and the consumer-marketplace literature

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The NOX-generated superoxide can be converted to other forms of ROS or detoxified by reduced glutathione and glutathione-coupled antioxidant enzymes, such as glutathione peroxidases (GPXs) and glutathione reductase (GR), to maintain redox homeostasis

Cebrian A, Pharoah PD, Ahmed S, Smith PL, Luccarini C, Luben R, Redman K, Munday H, Easton DF, Dunning AM, Ponder BA