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36-38 Low rates of hypoglycemia have been reported in clinical trials of SGLT-2 inhibitors, except in patients receiving therapy with background insulin or insulin secretagogues

Furthermore, GLP-1RA treatment in patients with T2DM has been linked to decreased secretion of pro-inflammatory cytokines, such as interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor- (TNF-) by peripheral blood mononuclear cells (PBMC) [75]

2015, doi: 10.3109/14647273.2015.1050462

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Together, they may offer a comprehensive approach to promoting skin resilience and vitality