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However, the expression of GPx1 has been reported to be down-regulated in thyroid cancer [44], colorectal cancer [45, 46], and gastric cancer [47], whereas GPx1 has been demonstrated to play an oncogenic role in kidney cancer [48], pancreatic cancer [49], and laryngeal squamous cell carcinoma [50]

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Due to these properties, they represent promising candidates for the development of more stable and efficacious research compounds, particularly when targeting proteinprotein interactions