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Participants who completed VESPER-1 were eligible to enroll in an exploratory open-label extension that evaluated higher weekly dosing (1.6 mg, 2.4 mg) and less frequent dosing (every other week and monthly)

External appeals have a higher overturn rate, particularly when clinical justification beyond BMI alone is strong (cardiovascular indication, sleep apnea documented by sleep study, or other comorbidities)

[DOI] [PMC free article] [PubMed] [Google Scholar] 97.Academy of Nutrition and Dietetics

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Going below 1,500 risks nutrient deficiency, excessive fatigue, and metabolic adaptation that will ultimately slow weight loss

If that sounds familiar, you're probably anxious to start losing weight