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reported that MYCN stimulates the transsulfuration pathway through the induction of the key enzymes CBS and methylthioadenosine phosphorylase, and further protects neuroblastomas from ferroptotic cell death (53)

Dos Santos C, Karagiannopoulos A, Rafacho A, et al

Factors affecting symptom duration include dietary modifications, hydration status, concurrent medications, and individual gastrointestinal sensitivity

Common adverse events reported in clinical trials include gastrointestinal disturbances such as nausea, vomiting, and diarrhea, which may affect adherence to treatment [36]