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The results showed that ROSE-010 (100 g) significantly reduced pain intensity in individuals with IBS compared to a placebo, with an overall odds ratio of 2.30 (95% CI: 1.53-3.46) and ROSE-010 (300 g) demonstrated greater effectiveness than placebo across all IBS subtypes, with consistent findings across multiple trials

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To determine if the non-functional mutants were expression or trafficking deficient, we analyzed the surface expression of all the mutants by biotinylation assay

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