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The plausibility of this hypothesis is indirectly supported by the observation that salmon calcitonin, a high-affinity agonist, displays slower G protein release kinetics, and thus lower efficacy, than human calcitonin, a lower-affinity agonist

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Schneider P, Weber-Fahr W, Schweinfurth N, Ho YJ, Sartorius A, Spanagel R, et al

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