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No developmental toxicities were observed in rabbits at doses up to 180 mg/kg/day (1191-times the 10 mg clinical dose, based on AUC)

This is particularly relevant given the significant media attention surrounding GLP-1 receptor agonists and weight loss medications

[1] Ibuprofen belongs to the NSAID class and works by inhibiting cyclooxygenase (COX) enzymesspecifically COX-1 and COX-2which are responsible for producing prostaglandins

Barzilai N, Guo H, Mahoney EM, et al

Over-the-counter and herbal supplements Many products marketed for weight loss including those containing caffeine, green tea extract, glucomannan, or various herbal blends are not regulated as medicines in the same way as prescription products

Pinch and insert: Pinch a fold of skin