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This process repeats until all the diphenhydramine gets used up

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Current estimates suggest that its primary compound patent wont expire until around 2036, and on top of that, additional formulation-related patents may extend exclusivity even further

Christen S, Redeuil K, Goulet L, Giner MP, Breton I, Rota R, et al

35 A study evaluating the effect of blood glucose on cognitive effects in ARDS patients one year after hospital discharge demonstrated a significant association between blood glucose concentrations and cognitive sequelae, as evidenced by a longer duration of mechanical ventilation