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2010) for validation and/or optimization of the high-penalty parameters and charges, the energy of each system was minimized (Pan and Roux 2008) to remove any steric clashes or unusual geometry by steepest descent algorithm using the input parameter EM file (Hess et al

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But ive now found that the sub-cutaneous method works as well , using a short 6mm needle

The authors point to the systemic effects of these medications as one possible explanation for the findings