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Myriocin (also known as antibiotic ISP-1 and thermozymocidin) was isolated from thermophilic fungi such as Mycelia sterilia and Isaria sinclairii

Williams BL, Hornig M, Buie T, et al

For each gel, 300 g protein extract was mixed with rehydration buffer (8 M urea, 2% CHAPS, 0.5% IPG strip buffer, 15 mM dithiothreitol (DTT) and 0.002% bromophenol blue to a final volume of 450 L, and applied to 24 cm-IPG BlueStrip (Serva Electrophoresis) with a pH gradient of 310

The result is an abnormally wired brain

Another study demonstrated that caffeine reduces NLRP3 inflammasome activation by inducing autophagy in microglia [91], suggesting a potential mechanism for investigation in the context of mood disorders