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In the STEP and SURMOUNT trials: Constipation was reported in up to 24% of patients on semaglutide 18-23% of patients on tirzepatide experienced constipation It is one of the top three side effects of these medications and is more frequent in those who: Lose weight rapidly Eat low-fiber diets Are female (due to hormonal factors affecting gut motility) Conventional Treatment Approaches Most providers recommend over-the-counter (OTC) remedies such as: Stool softeners (docusate) Fiber supplements (psyllium, methylcellulose) Laxatives (PEG 3350, senna, Mag Citrate) These can help in the short term but do not address the root cause
Ascorbic acid typically reacts with oxidants, terminating chain radical reactions via electron transfer
Stable gastric pentadecapeptide BPC 157 may recover brain-gut axis and gut-brain axis function
Research Studies: The Science Behind GHK-Cu GHK-Cu is unusual among peptide compounds in having an exceptionally strong body of peer-reviewed research
doi: 10.1056/NEJM199610033351401
Some modulate inflammation and tissue repair, helping the body maintain balance rather than chronic low-grade inflammation (a key driver of aging)
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