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The FDA prescribing information does not mandate dose reduction before discontinuation, and there is no official evidence of withdrawal syndrome or rebound effects requiring gradual weaning
Studies show that single-molecule dual GIPR/GLP-1R agonists have better insulinotropic and antihyperglycemic effects than GLP-1 agonists in rodents, primates, and humans, without causing gastrointestinal disturbances [58]
In certain cases, supplementation with L-Carnitine may be beneficial, particularly for individuals with deficiencies or those with largely plant-based diets
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Lv Z, Wang F, Zhang X, Zhang X, Zhang J, Liu R
Other as yet uncharacterized proteins may also have DHAR activity (Morell et al
