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Margulies KB, Hernandez AF, Redfield MM et al (2016) Effects of Liraglutide on Clinical Stability Among Patients With Advanced Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial

Evidence from transgenic mice that glucokinase is rate limiting for glucose utilization in the liver

Curcumin interferes with several liver enzymes, particularly the Cytochrome P450 pathway (CYP3A4, CYP1A2), which can drastically alter how the body clears concurrent medications

These complications contribute to a high mortality rate relative to the general population [7,912]

Together, they may combine medical management, lifestyle coaching, and GLP-1 therapy where appropriate