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Firstly, they used the double-click chemistry strategy to staple -helical peptides derived from the tumor suppressor p53 for the inhibition of p53-murine double minute 2 (MDM2) interaction and introduced cationic arginine (Arg) residues on the staple linkage to improve the cell permeability and activate capability of p53

doi: 10.1016/j.jpeds.2011.08.004, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 59.Parikh P, Juul SE

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