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Key triggers include a high membrane potential (m) that favors electron leak, reverse electron transport (RET) during succinate overload, ischemiareperfusion transitions with abrupt redox and calcium shifts, sustained Ca overload, substrate re-routing that alters NADH/FADH 2 supply and activation of the redox adaptor p66^Shc (Robb et al

Increased Side Effects The most common side effects of these medications are gastrointestinal

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Both sides raise issues patients should understand