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3.4.2 Induction of apoptosis and inhibition of cancer cell proliferation Both -sitosterol and berberine inhibit cancer cell proliferation by inducing apoptosis through the mitochondria-mediated intrinsic pathway and blocking cell cycle progression (83)

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HGF is majorly distributed in the extracellular matrix of most tissues in its inactive form where it is cleaved by heparin-like proteoglycans to its mature form [29]

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