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Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulin-dependent) diabetic patients
Most patients who stop GLP-1 therapy for 2 to 4 weeks experience modest weight rebound, typically 2 to 5 pounds, though individual responses vary
Glucagon-like peptide 1 receptor activation suppresses appetite through direct action on the hypothalamus, delays gastric emptying to promote prolonged satiety, and improves insulin sensitivity
Why Muscle Preservation Matters After GLP-1 Weight Loss Muscle is one of the most important factors in long-term weight maintenance
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Furthermore, a meta-analysis of data from large cardiovascular outcome trials (CVOT) demonstrates that GLP-1RA therapy does not seem to elevate the risk of pancreatic cancer in patients with T2DM [7]
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