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Dehydration can exacerbate gastrointestinal issues, including stomach cramps

What Would Have to Be True for the Trial Numbers to Transfer For the Wegovy results to describe a compounded preparation, that preparation would need to contain the same active ingredient, at the delivered dose intended, with comparable bioavailability, administered on the same schedule, in a comparable population, alongside the same lifestyle intervention

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That said, their simultaneous use should be approached with caution

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A sub-study running inside the Phase 3 weight-loss trials is studying retatrutide in adults with obesity and moderate-to-severe sleep apnoea, but no results are available [7]