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Stromal-epithelial interactions during embryogenesis may influence the development of distinct melanocyte subpopulations that differ in anatomic distribution and the potential to evolve into various types of melanocytic proliferations (13,14,15,16,17,18 and 19), features that underscore the heterogeneous nature of malignant melanoma with respect to the different site-dependent features

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Normal blood vessels serve as conduits for the delivery of oxygen and nutrients

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Salsalate attenuates free fatty acid-induced microvascular and metabolic insulin resistance in humans

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