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In the structure of the GST-glutathione complex, two conserved water molecules are observed, one of which hydrogen bonds directly to the sulphur atom of glutathione and the other forms hydrogen bonds with residues around the glutathione-binding site

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The REMS was set to go into effect on 8 August, but the agency said it wants to allow more time to test the iPLEDGE REMS system updates, minimize technical issues for iPLEDGE REMS platform users, and ensure patients continue to have access to isotretinoin treatment

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