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Induction of Type 1 Diabetes T1DM was induced by a single intraperitoneal injection of 135 mg alloxan (kg body mass) 1 dissolved in 0.2 mL sterile saline 22

References Dimopoulos MA, San-Miguel JF, Anderson KC

Whang, E

In summary, the targeted modulation of microbial dysbiosis during the AKI-to-CKD transition represents an effective strategy to prevent CKD development by enhancing intestinal integrity, reducing inflammation, and promoting metabolic homeostasis

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It is essential to recognize that most current evidence comes from preclinical models or small human studies with methodological limitations