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Semaglutide GLP-1 mimics a natural hormone called GLP-1, which regulates appetite, food intake, and blood sugar levels

Inactivation of the carcinogen, 5-hydroxymethylchrysene, by glutathione conjugation via a sulphate ester in hepatic cytosol

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Isla et al [4] used the same gradient strategy

Beyond the initial approvals (FDA 2017, EMA 2018), real-world evidence confirms the clinical benefits of semaglutide, while ongoing post marketing has thus far revealed no unexpected safety signals