All GLP-1 RAs include an FDA boxed warning for increased risk of development of medullary thyroid carcinoma (MTC) based on early murine studies
If you have severe obesity, have plateaued on semaglutide or tirzepatide, or have overlapping metabolic conditions like fatty liver disease, retatrutide is the stronger intervention
The potential investment of the PBS into reducing the significant burden of disease and economic burden of obesity could be in the order of multiple billions over the forward estimates, Novo Nordisk said in its pitch to get Wegovy subsidised by the PBS
This stimulates the sympathetic nervous system, which leads to the secretion of adrenaline by the adrenal marrow and ACTH by the hypothalamus so that more cortisol is secreted
Injecting on a very full stomach may increase nausea risk
A 2018 clinical study: In the study of 71 women, a facial cream containing GHK-Cu was applied daily for 12 weeks