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Glutathione is a small, polar molecule (~307 Da) , a size and structure that generally favors absorption through the nasal mucosa without needing strong chemical enhancers

Insufficient buffering: Reconstituting GHK-Cu without adequate bacteriostatic saline, or using a solvent that does not adequately buffer the solutions pH, leaves the compound in a form that is more likely to cause tissue irritation on delivery

Primary changes appear

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We found seven cases that developed renal disease (Figure 6): four had AKI (57.1%), two (28.6%) had rhabdomyolysis, one (14.3%) had hyponatraemia followed by a coma