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Equally importantly, GLP-1 receptor agonist use was associated with some increased risks compared to usual care with other treatments

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Who Might Not Be Suitable for Semaglutide: Pregnant or Breastfeeding Women: Semaglutide's safety during pregnancy and breastfeeding hasn't been extensively studied

Compared to continued use of GLP-1s for three years, which corresponded to an 18% risk reduction, GLP-1 users who experienced interruption and subsequently resumed gained a 12% risk reduction on average

Movahedi F, Wu Y, Gu W, et al

The presence of partial or complete anorexia, which occurs in many animals with CHF, can dramatically alter diet choice