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Both direct markers, including pyruvate, lactate, lactate-to-pyruvate ratio, alanine, alanine-to-lysine ratio, acyl-carnitines, and ubiquinone, and indirect markers, such as ammonia, carnitine, creatine kinase, alanine aminotransferase, and aspartate aminotransferase, have been used to identify these dysfunctions [91]

Moreover, glutathione levels can be influenced by various factors, including diet, lifestyle, and environmental toxins

NR protects mice from HFD-induced body weight gain, enhances the liver weight regain by promoting hepatocyte replication and increasing hepatic ATP content in the regenerating liver