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The Diabetes, Obesity, and Metabolism study that identified the rise in off-label use noted that GLP-1 therapies could cause people with type 1 diabetes to experience unpredictable blood sugar levels, nausea, and even diabetic ketoacidosis

While insured patients may see overall lower costs of therapy, the out-of-pocket expenses can vary significantly, ranging from nominal copays to hefty cost sharing for medications indicated primarily for weight loss