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Weight reduction that is substantial (14 %) and rapid (over 34 months) is associated with significant bone loss [67], while more moderate and slower weight reduction may better preserve bone mass [68]

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This work was supported by the National Institute of Diabetes, Digestive and Kidney Diseases R00DK1208689 and P30DK045735 grants, the National Institute of Health Yale-Murine Tissue Mapping Center Grant U54 AG079759 and the National Institute of Health National Institutes of Aging Grant P30AG066508