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Prescription medicines like semaglutide (injectable) and tirzepatide (injectable) produce much larger average reductions in many high-quality trials

t 22 =1.37, P=0.183

B12 Supplementation Strategies for Tirzepatide Users Oral B12 supplements (methylcobalamin or cyanocobalamin) are the simplest option and work well for most people on tirzepatide, assuming adequate stomach acid and intrinsic factor production

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Your provider will review your medications and advise accordingly

They can help you rule out or confirm any other reasons for constipation