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On the other hand, ROS can also induce cellular senescence and cell death and can therefore function as anti-tumorigenic agents

Wang TS, Grubbs EG, McGill JF, Solorzano CC, Sturgeon C, Zafereo ME

Loss of lean body mass, especially muscle, can contribute to frailty, sarcopenia and metabolic decline, all of which are particularly troubling in aging populations or individuals with low baseline muscle mass

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In conclusion, advancing these priority areas will catalyze a paradigm shift in DKD carefrom controlling progression to targeting disease mechanisms, and from standardized treatment to personalized, precision-based approaches