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GLP-1 medications work by helping regulate appetite and blood sugar, allowing you to eat less and feel fuller for longer periods

This includes personalized dietary guidance, tailored physical activity plans, and behavioral strategies to support your journey

As ligand-specific GLP-1R conformations are a further potential explanation for the ligand signalling efficacy differences, we devised a strategy to monitor movements between the receptor ECD and the plasma membrane, finding efficacy reductions with exendin-4-C16 that matched the reduced intracellular signalling responses also observed with this ligand