The ARC, a key site of the hypothalamus, receives direct signals from the periphery, and it contains both orexigenic neurons expressing Agouti-related peptide (AgRP)/NPY and anorexigenic neurons expressing POMC (27)
Nature Medicine, 28(11), 22222233
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This activity alters with aging, decrease with BMI, differs in diabetes, cardiovascular events, even lifestyle, which should be considered in this kind of research