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Contraindications include active malignancy (GH/IGF-1 could theoretically promote tumor growth, though evidence is mixed), hypersensitivity to Sermorelin or GHRH, pituitary tumors or masses (stimulation could theoretically promote growth), and pregnancy/lactation (safety not established)

These findings collectively suggest that targeting the ZHX2-YTHDF2 loop may be a promising therapeutic approach for managing MASLD in patients with diabetes

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Banerjee, A., Santra, D