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Studies have revealed that glutamate can trigger the expression of immunosuppressive genes, including STAT3, ARF4, and RAB10, in neutrophils, which promotes their immunosuppressive phenotype [175]

Even though alternative models are available, such as animal models or ex vivo models, in vitro models offer higher experimental flexibility and reproducibility, making them a valuable tool for the understanding of pathophysiological mechanisms of several diseases, such as CVDs

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Clin Nutr 8:8387 Tao RC, Peck GK, Yoshimura NN (1981) Effect of carnitine on liver fat and nitrogen balance in intravenously fed growing rats

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Inflamm Bowel Dis