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When the gut lining is inflamed and permeable, neurotransmitter production is disrupted, inflammatory cytokines cross into systemic circulation and reach the brain, and the vagus nerve the primary communication cable between gut and brain transmits distress signals that manifest as anxiety, brain fog, and fatigue

Unfortunately, many of these claims are not backed by clinical evidence

In people with obesity or insulin resistance, the function of this hormone can be weaker

doi: 10.1016/j.phrs.2012.11.005 59 DavisD