This raises the question: does l-carnitine cause heart problems
The incidence of side effects in the Lcarnitine group was significantly higher than in the placebo group (18% vs 4%, P = 0.025)
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doi:10.1016/s0033-0620(97)80037-0 Fisher JS, Gao J, Han DH, Holloszy JO, Nolte LA
When safety of the study participants and technological developments allow, so called biomarkers can be used to collect PD data to understand if the drug reaches the target, binds to the target and exerts its expected pharmacological activity within the dose range tested
The relative ranking of the different treatment was estimated for each outcome using p-score [22]