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Aging Cell 15 , 416427 (2016)

Using a collagen gel contraction assay, we observed that primary fibroblasts from the lungs of aged GHK-treated mice exhibited enhanced contraction compared to fibroblasts from placebo-treated mice (Figure 4), further supporting the hypothesis that GHK promotes the resolution of collagen scars

The 28-day window is based on stability studies showing that peptide degradation in aqueous bacteriostatic solution remains below 5% at refrigerated temperatures for this duration

Dynamic changes in DNA methylation of extrinsic factors seem to have a role in the regulation of neuronal proliferation and survival

Gynotoxic effects of chemotherapy and potential protective mechanisms

Western blot Cells were harvested and proteins were extracted using cell lysis buffer supplemented with 0.3% phenylmethylsulfonyl fluoride and proteinase and phosphatase inhibitors