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it involves central and peripheral sensitization

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These observations are consistent with the relative affinities of the sensor variants determined in vitro ( Figure 1 ) and suggest robust and active maintenance of NADP redox state even under severe oxidative challenge, which is in stark contrast to previous observations of a highly volatile cytosolic NAD redox state as monitored by Peredox [13, 23]

Naunyn Schmiedebergs Arch Pharmacol 398(8):1026110272

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